Plus tablets, as provided by Douglas Laboratories®, dissolve rapidly in
the mouth, releasing 1,000 mcg of pure Vitamin B12 together with 400
mcg of Folic Acid.
Sublingual-12 Plus tablets may be a useful dietary
supplement for individuals who wish to increase their intake of Vitamin
B12 and folate.
Vitamin B12 is essential for normal energy
metabolism of carbohydrate, fat and protein. As a cofactor for
methylmalonyl-CoA mutase enzymes, vitamin B12 helps convert odd chain
fatty acids and branched chain amino acids into succinyl-CoA, a common
citric acid cycle intermediate. Vitamin B12 is also required for
nucleic acid (DNA) synthesis, methionine synthesis from cysteine, and
normal myelin synthesis in the nervous system. Along with Vitamin B6
and folic acid, adequate levels of vitamin B12 are required to maintain
normal plasma homocysteine levels. Elevated plasma homocysteine may be
an independent risk factor for developing cardiovascular disease.
are two distinct mechanisms for intestinal Vitamin B12 absorption;
receptor-mediated absorption and passive diffusion. In the first,
Vitamin B12 attaches to a salivary “R-binder” protein which transports
it into the small intestine, where Vitamin B12 is released. The vitamin
then binds to “Intrinsic Factor” (IF), a glycoprotein normally produced
by the gastric parietal cells. This Vitamin B12-IF complex is carried
down to the ileum, where it binds to mucosal receptors. Finally, the
complex is absorbed and bound to serum vitamin B12-binding proteins.
second absorption mechanism, passive diffusion, does not require any
carriers, such as B-binder or IF. Only about 1% of free vitamin B12 is
passively absorbed, but this can be nutritionally significant with
higher dietary vitamin B12 intakes. Almost 40% of the population is
suggested to have “low normal” plasma B12 levels. Strict vegetarians,
the elderly, and, HIV/AIDS patients are often at risk for vitamin B12
deficiency, either due to low dietary intake or impaired absorption. In
the elderly, hypo- or achlorhydria maintains the binding of the vitamin
with dietary proteins, leading to malabsorption. Vitamin B12 deficiency
can lead to CNS impairment, including cognition.
Each Tablet Contains:
Vitamin B12 ...1,000mcg
Folic Acid ...400mcg
Adults take 1 tablet daily or as directed by a physician. Let tablet dissolve in mouth.
These statements have not been evaluated by the Food and Drug
Administration. These products are not intended to diagnose, treat
cure, or prevent any diseases.