capsules, provided by Douglas Laboratories®, contain a complementary
blend of Thiamin, Biotin, Chromium, Alpha-Lipoic Acid,
N-acetyl-L-cysteine, and standardized extract of Gymnema Sylvestre leaf
for targeted nutritional support of glucose metabolism.
may be a useful dietary supplement for those who wish to support
nutritional control of healthy blood sugar metabolism.
is the non-enzymatic attachment of sugars to major molecules in the
body, including proteins, lipids, and nucleic acids. Glycation
reactions generate advanced glycation end-products (AGE’s) and
glycotoxin intermediates. AGE’s can cause abnormal and destructive
functioning of body proteins, lipids, and nucleic acids. AGE associated
damage is suspected in the pathogenesis of many diseases and
AGE’s can be created endogenously,
often as a consequence of excessive blood glucose levels. AGE’s are
also present in browned foods and cured tobacco. As uncontrolled blood
glucose levels give rise to the formation of dangerous AGE’s, it is
crucial to maintain blood glucose levels within normal, healthy limits
to avoid excessive AGE induced damage. Maintenance of normal blood
glucose levels is fundamental to preventing AGE formation. Chromium is
an integral component of the glucose tolerance factor (GTF), a
naturally occurring compound of chromium, nicotinic acid, and amino
acids that is essential for proper glucose metabolism.
chromium nutrition is essential for the formation of GTF and subsequent
healthy metabolism of normal blood glucose levels. Biotin serves as a
cofactor of glucose metabolism and induces glucokinase, an enzyme that
encourages cells to retain glucose for energy production rather than
release it into the blood stream. Alpha-lipoic acid appears to enhance
glucose use by muscles by augmenting muscle protein content. Gymnema
sylvestre is an Ayurvedic botanical that may assist in the normal
regeneration and repair of healthy pancreatic beta cells. Gymnema may
also support healthy intestinal glucose absorption.
nutrients help to directly arrest glycation reactions. A derivative of
thiamin (vitamin B1), called thiamin pyrophosphate, and alpha-lipoic
acid have both been shown to prevent in vitro AGE production. Also
crucial to controlling AGE formation and subsequent damage is
antioxidant protection. Oxidative stress is closely related to AGE
production and is a known contributing factor to many of the same
health concerns thought to be associated with AGE damage. In vitro
studies of N-acetyl-L-cysteine have documented inhibition of glycation
induced damage to pancreatic cells. N-acetyl-L-cysteine is a potent
antioxidant, serving as an intracellular precursor of glutathione.
Two Vegetarian Capsules contain:
Thiamine (pyrophosphate) ...50mg
Chromium (ChromeMate® polynicotinate*) ...800mcg
Alpha-Lipoic Acid** ...200mg
Gymnema Sylvestre Leaf ...400mg
dried extract, 25% gymnemic acids
2 capsules, three times daily at the start of a meal, or as directed by physician.
These statements have not been evaluated by the Food and Drug
Administration. These products are not intended to diagnose, treat
cure, or prevent any diseases.