provided by Douglas Laboratories, supplies a synergistic combination of
Gymnema sylvestre, fenugreek and cinnamon extracts designed to support
healthy blood sugar metabolism.
GlucoBrium may be a useful dietary
supplement for individuals wishing to support healthy blood sugar
metabolism with this unique blend of ingredients.
metabolism that is associated with abnormally high blood glucose can
lead to high levels of glycation. Glycation is the non-enzymatic
attachment of sugars to major molecules in the body, including
proteins, lipids, and nucleic acids. Glycation reactions generate
advanced glycation end-products (AGEs) and glycotoxin intermediates.
AGEs cause abnormal and destructive functioning of body proteins,
lipids, and nucleic acids. AGE-associated damage is suspected in the
pathogenesis of many diseases and age-related deteriorations.
sylvestre is an Ayurvedic botanical that may assist in the normal
regeneration and repair of healthy pancreatic beta cells. Gymnema is
also suspected of reducing intestinal glucose absorption. Native to
India, this woody, climbing plant has been used traditionally in India
to treat madhu meha, or “honey urine.” Gymnemic acid, an active
component of Gynema sylvestre, has been identified in numerous animal
studies as having anti-hyperglycemic effects.
have indicated it may be useful in healthy glucose metabolism.
Fenugreek, a popular spice in Asia and Europe, contains a high
percentage of mucilage, a soluble dietary fiber. Soluble dietary fiber
plays important roles in the digestive system, helping to inhibit the
absorption of sugars and fats and causing blood sugar levels to rise at
a slower rate. In studies using diabetes-induced rats, preparations of
fenugreek caused a reduction in postprandial elevation in blood
glucose, mainly by delaying the digestion of sucrose.
animal studies indicate that the active ingredient,
4-hydroxyisoleucine, may also play important roles in supporting
pancreatic beta-cells during insulin secretion. Human studies have also
indicated that fenugreek plays supportive roles in blood sugar and
cholesterol metabolism. Recently, cinnamon, a well-known spice and
flavoring, has been gaining attention for its roles that it plays in
supporting the body’s metabolism of glucose. In one study, patients
given cinnamon showed significant decreases in fasting glucose,
triglycerides and cholesterol.
Another study has indicated
that cinnamon may be a strong potentiator of insulin. Interestingly,
while preliminary studies have identified methyl hydroxyl chalcone
polymer(MCHP) as the primary active ingredient, more recent studies
have indicated that this molecule may have been incorrectly identified.
The active ingredients are now believed to be primarily water-soluble
proanthocyanidin type-A polymers. Since proanothocyanidins have
excellent antioxidant potential, cinnamon may offer both the benefits
of supporting blood sugar metabolism, as well as providing significant
antioxidant protection to the cell.
While the safety of whole
cinnamon spice is well known, there is some concern that long term use
of amounts greater than that used in cooking may lead to potential
toxic buildup. GlucoBrium contains Cinnulin PF™, a patented
water-soluble cinnamon extract that is processed using a unique
extraction method to remove any potential toxins that whole cinnamon
1 Vegetarian Capsule contains:
Standardized Gymnema Extract ...200mg
(40% gymnemic acids, leaf)
Fenugreek Extract ...125mg
(standardized to 20% 4-hydroxyisoleucine)
Cinnamon Extract (Cinnulin PF)™ ...125mg
Adults take 1-2 capsules daily with meals or as directed by a physician.
These statements have not been evaluated by the Food and Drug
Administration. These products are not intended to diagnose, treat
cure, or prevent any diseases.