Description: DHEA Plus 100c is available by Douglas Laboratories.
amni® original formula
A Dietary Supplement
DHEA Plus capsules,
provided by Douglas Laboratories®, contain 25 mg each of highest purity
dehydroepiandrosterone (DHEA) and pregnenolone. Both are produced under
strict Good Manufacturing Practices (GMP) standards.
DHEA plus capsules may be a useful
nutritional supplement for individuals who wish to support the body’s
normal DHEA and pregnenolone functions.
DHEA is a natural steroid hormone that
is synthesized from cholesterol through pregnenolone by the adrenal
glands. DHEA acts as an antagonist for glucocorticosteroid hormones and
is the parent precursor for other important steroid hormones, such as
estradiol and other estrogens, and testosterone. While not a precursor
to progesterone, DHEA can indirectly influence progesterone synthesis
through a feedback mechanism where pregnenolone is converted to
progesterone based on DHEA levels.
Apart from these functions,
DHEA also has important biological functions itself. Recent
experimental and human studies show that DHEA is involved in large
variety of physiological processes, including immune system, brain
function, bone metabolism, blood lipid metabolism, energy metabolism,
the regulation of normal blood sugar and insulin levels, and the
maintenance of lean body mass. DHEA and its metabolite DHEA sulfate are
present in human adult plasma in concentrations of 0.01-0.02 ìM and 5 -
7 ìM, respectively.
DHEA sulfate levels are low in early
childhood, begin to rise after 7, peak at age 20-24, and the drop at a
rate of approximately 20% per decade, until at age 85-80, levels are
10- 15% of what they used to be at age 20-30. DHEA levels also decline
under a variety of conditions of physiological stress, such as acute
and chronic infections, and trauma. Vegetarians have been shown to have
decreased DHEA levels as well. Pregnenolone is often referred to as the
grandparent precursor to steroid hormones in mammals. Pregnenolone is
synthesized from cholesterol in the mitochondria of adrenal glands.
is also made to a lesser extent in the brain, liver, skin, testes and
ovaries. Once synthesized, pregnenolone is released from the
mitochondria into the cytosol where it can be converted to DHEA
(dehydroepiandrosterone) or to progesterone. Progesterone is the
precursor to cortisol, aldosterone, androstenedione, estrogen, and
testosterone. Pregnenolone may also be secreted directly into the blood
where it circulates primarily as the sulfated form. Pregnenolone has
many actions of its own not attributable to its conversion to
progesterone or to DHEA.
Recent studies show that pregnenolone
is important for the function of brain, nervous tissue, liver,
pancreas, reproductive tissues, pituitary and skin. Pregnenolone is
found in higher concentrations in the central nervous system compared
to the peripheral tissues which may reflect its importance in brain
function. As with DHEA, pregnenolone production declines with age. It
is estimated that pregnenolone production is about 60% less at age 75
than at age 35. Pregnenolone levels may also decline under various
conditions of physiological stress, such as acute and chronic
infections and trauma. Supplementation of DHEA and pregnenolone
together may assist the body’s natural homeostatic balance of these
hormones and subsequent metabolism.
Serving Size: 1 capsule
Servings Per Container: 100
Amount Per Serving
* Daily Value not established
Cellulose, Gelatin (capsule), Water, Magnesium Stearate
As a dietary supplement, take 1-2 capsules daily, or as directed by the physician.
NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS.
DO NOT USE IF PREGNANT OR NURSING.
Consult a physician or licensed
qualified health care professional before using this product if you
have a family history of breast cancer, uterine cancer, ovarian cancer,
prostate cancer, prostate enlargement, heart disease, low HDL
cholesterol ("good cholesterol"), or if you are using any other dietary
supplement, prescription drug, or over-the-counter drug.
Do not exceed the recommended serving.
Exceeding the recommended serving may cause serious adverse health
effects. Possible side effects include changes in liver function, acne,
hair loss, hair growth on the face (in women), aggressiveness,
irritability, and increased levels of estrogen. Discontinue use and
call a physician or licensed qualified health care professional
immediately if you experience rapid heartbeat, dizziness, blurred
vision, or other similar symptoms.
KEEP OUT OF REACH OF CHILDREN.
For optimal storage conditions, store in a cool, dry place.
Tamper resistant package, do not use if outer seal is missing.
(35-65% relative humidity)
These statements have not been evaluated by the Food and Drug
Administration. These products are not intended to diagnose, treat
cure, or prevent any diseases.