Description: B-12 500mcg 100t is available by Douglas Laboratories.
Vitamin B-12 Tablet
A Dietary Supplement
Vitamin B12 tablets, provided by Douglas Laboratories, supply 500 mcg of Vitamin B-12 in each easy to swallow tablet.
Vitamin B-12 may be a useful dietary supplement for individuals who wish to increase their intake of Vitamin B12.
Vitamin B12 is essential for normal
energy metabolism of carbohydrate, fat and protein. As a cofactor for
methylmalonyl-CoA mutase enzymes, vitamin B12 helps convert odd chain
fatty acids and branched chain amino acids into succinyl-CoA, a common
citric acid cycle intermediate. Vitamin B12 is also required for
nucleic acid (DNA) synthesis, methionine synthesis from cysteine, and
normal myelin synthesis in the nervous system.
Vitamin B6 and folic acid, adequate levels of Vitamin B12 are required
to maintain normal plasma homocysteine levels. Elevated plasma
homocysteine may be an independent risk factor for developing
cardiovascular disease. There are two distinct mechanisms for
intestinal Vitamin B12 absorption; receptor-mediated absorption and
passive diffusion. In the first, vitamin B12 attaches to a salivary
“R-binder” protein which transports it into the small intestine, where
vitamin B12 is released.
The vitamin then binds to “Intrinsic
Factor” (IF), a glycoprotein normally produced by the gastric parietal
cells. This vitamin B12-IF complex is carried down to the ileum, where
it binds to mucosal receptors. Finally, the complex is absorbed and
bound to serum vitamin B12-binding proteins. The second absorption
mechanism, passive diffusion, does not require any carriers, such as
B-binder or IF. Only about 1% of free vitamin B12 is passively
absorbed, but this can be nutritionally significant with higher dietary
vitamin B12 intakes. Almost 40% of the population is suggested to have
“low normal” plasma B12 levels.
Strict vegetarians, the elderly,
and, HIV/AIDS patients are often at risk for vitamin B12 deficiency,
either due to low dietary intake or impaired absorption. In the
elderly, hypo- or achlorhydria maintains the binding of the vitamin
with dietary proteins, leading to malabsorption. Vitamin B12 deficiency
can lead to CNS impairment, including cognition.
Serving Size: 1 tablet
Servings Per Container: 100
Amount Per Serving
Vitamin B-12 ...500mcg
Cellulose, Vegetable Stearate, Silica
Does Not Contain:
Yeast, Wheat, Gluten, Soy Protein, Milk/Dairy, Corn, Sodium, Sugar, Starch, Artificial Coloring, Preservatives, Flavoring
As a dietary supplement, adults take1 tablet 1 ot 2 times daily or as directed by your healthcare professional.
KEEP OUT OF REACH OF CHILDREN.
For optimal storage conditions, store in a cool, dry place.
Tamper resistant package, do not use if outer seal is missing.
(35-65% relative humidity)
These statements have not been evaluated by the Food and Drug
Administration. These products are not intended to diagnose, treat
cure, or prevent any diseases.